TABLE 2.
Physical Exam, Symptoms, Health Status, Exercise Capacity, and Laboratory Data
| Total (N = 626) | RELAH (n = 444) | EILAH (n = 182) | P Value | |
|---|---|---|---|---|
| Height, cm | 167.3 (160.0–174.2) | 167.6 (160.0–175.0) | 165.3 (160.0–174.0) | 0.42 |
| Weight, kg | 89.8 (76.9–105.0) | 91.0 (77.0–105.1) | 87.6 (76.0–102.1) | 0.056 |
| Body mass index, kg/m2 | 32.0 (27.7–37.0) | 32.2 (28.0–37.4) | 31.6 (27.1–35.7) | 0.074 |
| Body surface area | 2.0 (1.9–2.2) | 2.0 (1.9–2.2) | 2.0 (1.8–2.2) | 0.067 |
| Heart rate, beats/min | 70 (63–80) | 70 (62–80) | 70 (63–79) | 0.82 |
| Systolic blood pressure, mm Hg | 143 (128–158) | 145 (131–160) | 137 (125–152) | 0.001 |
| Diastolic blood pressure, mm Hg | 74 (67–83) | 74 (67–83) | 75 (68–81) | 0.57 |
| NYHA functional class | 0.22 | |||
| II | 132 (21.4) | 88 (20.1) | 44 (24.6) | |
| III | 484 (78.6) | 349 (79.9) | 135 (75.4) | |
| MAGGIC risk score | 23 (18–26) | 23 (19–27) | 21 (17–25) | <0.001 |
| KCCQ clinical summary score at baseline | 50.0 (35.4–67.1) | 49.5 (34.9–66.9) | 52.1 (36.5–67.2) | 0.57 |
| KCCQ overall summary score at baseline | 45.8 (29.2–62.5) | 45.8 (28.5–62.2) | 44.5 (30.2–63.5) | 0.82 |
| 6MWD at baseline, m | 301.3 (236.0–380.0) | 295.5 (225.0–367.8) | 326.2 (263.0–415.0) | <0.001 |
| H2FPEF score | 6 (5–8) | 6 (5–8) | 5 (4–6) | <0.001 |
| At least 1 hospitalization for HF in the past 12 months | 171 (27.3) | 113 (25.5) | 58 (31.9) | 0.10 |
| BNP, atrial fibrillation/flutter, pg/mL | 213.5 (119.0–380.3) | 216.8 (126.7–425.0) | 160.3 (81.8–305.6) | 0.36 |
| BNP, sinus rhythm, pg/mL | 91.9 (40.8–170.0) | 110.0 (60.0–220.0) | 56.0 (29.3–104.6) | <0.001 |
| NT-proBNP, atrial fibrillation/flutter, pg/mL | 1,147.5 (643.0–1,792.0) | 1,225.0 (647.0–1,900.0) | 721.0 (453.5–965.5) | 0.026 |
| NT-proBNP, sinus rhythm, pg/mL | 329.0 (158.3–653.0) | 405.0 (200.0–788.0) | 215.0 (104.6–427.0) | <0.001 |
| Hemoglobin, g/dL | 12.7 (11.4–13.8) | 12.7 (11.3–13.8) | 12.7 (11.6–13.8) | 0.70 |
| eGFR, mL/min/1.73 m2 | 56.5 (42.0–68.0) | 55.0 (40.0–66.0) | 60.0 (46.5–69.5) | 0.005 |
| Estimated plasma volume, mL | 3,234 (2,834–3,649) | 3,152 (2,808–3,458) | 0.039 |
Values are median (IQR) or n (%). Values of P < 0.03 are considered to be significantly different after adjustment for multiple comparisons using the false discovery rate method.
6MWD = 6-minute walk distance; BNP = B-type natriuretic peptide; eGFR = estimated glomerular filtration rate; HF = heart failure; KCCQ = Kansas City Cardiomyopathy Questionnaire; MAGGIC = Meta-Analysis Global Group in Chronic Heart Failure; NT-proBNP = N-terminal pro– B-type natriuretic peptide; other abbreviations as in Table 1.