TABLE 5.

Efficacy Outcomes Stratified by Eilah Status Alone and Combined With Responder Subgroups

	Sham/IASD, n	Win Ratio	95% CI	P Value	HF Event, IRR	95% CI	P Value	Change in KCCQ	95% CI	P Value
EILAH
All EILAH	88/92	1.06	0.73–1.53	0.78	0.70	0.28–1.70	0.43	−0.1	−5.8 to 5.7	0.98
EILAH + peak PVR <1.74 WUs	59/67	1.46	0.93–2.29	0.10	0.52	0.18–1.50	0.23	+6.1	−0.5 to 12.7	0.07
EILAH + no pacemaker	77/79	1.10	0.74–1.63	0.64	0.59	0.21–1.68	0.32	−1.0	−7.2 to 5.2	0.76
EILAH + peak PVR <1.74 WUs and no pacemaker	50/57	1.56	0.96–2.54	0.08	0.53	0.15–1.85	0.32	+5.6	−1.6 to 12.7	0.13
RELAH
All RELAH	224/217	0.98	0.78–1.23	0.85	1.44	0.92–2.25	0.11	+1.3	−2.5 to 5.1	0.50
RELAH + peak PVR <1.74 WUs	123/132	1.25	0.92–1.70	0.15	0.73	0.39–1.35	0.32	+4.9	−0.1 to 9.9	0.06
RELAH + no pacemaker	184/166	1.12	0.86–1.45	0.39	1.22	0.71–2.09	0.47	+2.7	−1.6 to 6.9	0.23
RELAH + peak PVR <1.74 WUs and no pacemaker	102/103	1.51	1.07–2.13	0.02	0.44	0.02–0.99	0.047	+6.0	0.3–11.7	0.04

IASD = interatrial shunt device; IRR = incidence rate ratio; other abbreviations as in Tables 1, 2, and 4.