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. 2024 Jun 16;15(1):2360196. doi: 10.1080/19491034.2024.2360196

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© 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Structure of human eIF4E proteins binding the m7G cap with indication of the cap-binding site, the positively charged patch, and the dorsal surface. Selected interacting proteins are indicated for each of these domains. — The human eIF4E structure binding the m⁷G cap (in red) and known interactions: eIF4E structure and relative position of regions utilized by known partner proteins. The red arrow indicates the cap-binding site with the associated tryptophans in light blue, the purple arrow indicates the positively charge patch, where Importin 8, VPg and EG5 bind with the 2 lysines and the arginine shown. The dorsal surface is also shown and as is the surface used by the NC (non- canonical domain) of eIF4G and 4EBPs with gold yellow arrows (Adapted from [52], PDB3AM7).