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. 2024 Jun 16;15(1):2360196. doi: 10.1080/19491034.2024.2360196

Figure 3.

On the left, the major mRNA nuclear maturation steps are shown noting the involvement of eIF4E, as well as specific interacting partners discussed in the text. See the text for more details. On the right, the numbers of mRNAs coding for proteins involved in different mRNA processing steps that are targeted by eIF4E observed in nuclear, endogenous eIF4E-RIP-Seq and/or differentially spliced in AML patients based on eIF4E levels.

eIF4E can directly influence RNA fate or indirectly through its capacity to terraform the RNA processing landscape. On the left, interactions between eIF4E target mRNAs and the noted machineries are shown. On the right, numbers of mRNAs in a given process were identified in nuclear, endogenous eIF4E RIP-Seq [54] GSE63265_LY1_4EIP_allreps_counts.Txt.gz and/or RNA-seq splicing data segregated on high and normal-eIF4E AML specimens [100] (https://leucegene.ca/). These strongly suggest that eIF4E can influence a broad array of factors responsible for RNA processing thereby terraforming the RNA processing landscape. Functional categories were assigned using Metascape (metascape.Org).