Table 2.
Summary of RNA processing factors that are regulated by eIF4E.
| Sensitive Factor | eIF4E elevation | eIF4E reduction | Cell/tissue | Mode of eIF4E mediated regulation | Process | Doi |
|---|---|---|---|---|---|---|
| RPL13 | elevation | reduction | NIH3T3, MEFs | - | Translation | 10.1371/journal.pone.0000242 |
| RPL23 | elevation | reduction | NIH3T3, MEFs | Translation | Translation | 10.1371/journal.pone.0000242 |
| RPL26 | elevation | reduction | NIH3T3, MEFs | - | Translation | 10.1371/journal.pone.0000242 |
| RPL29 | elevation | reduction | NIH3T3, MEFs | - | Translation | 10.1371/journal.pone.0000242 |
| RPL32 | elevation | reduction | NIH3T3, MEFs | - | Translation | 10.1371/journal.pone.0000242 |
| RPL34 | elevation | reduction | NIH3T3, MEFs | Translation | Translation | 10.1371/journal.pone.0000242 |
| RPL35 | elevation | reduction | NIH3T3, MEFs | - | Translation | 10.1371/journal.pone.0000242 |
| RPL39 | elevation | reduction | NIH3T3, MEFs | - | Translation | 10.1371/journal.pone.0000242 |
| RanBP2 | reduction | elevation | U2OS | indirect protein stability | Nuclear transport | 10.1016/j.celrep.2012.07.007 |
| RanBP1 | elevation | reduction | U2OS | export | Nuclear transport | 10.1016/j.celrep.2012.07.007 |
| Gle1 | elevation | reduction | U2OS | export | Nuclear transport | 10.1016/j.celrep.2012.07.007 |
| DDX19 | elevation | reduction | U2OS | export | Nuclear transport | 10.1016/j.celrep.2012.07.007 |
| CPSF1 | elevation | - | U2OS | export | CPA | 10.1016/j.celrep.2019.04.008 |
| CPSF2 | elevation | - | U2OS | export | CPA | 10.1016/j.celrep.2019.04.008 |
| CPSF3 | elevation | - | U2OS | export | CPA | 10.1016/j.celrep.2019.04.008 |
| CPSF4 | elevation | - | U2OS | - | CPA | 10.1016/j.celrep.2019.04.008 |
| FIPL1 | elevation | - | U2OS | export | CPA | 10.1016/j.celrep.2019.04.008 |
| SYMPL | elevation | - | U2OS | export | CPA | 10.1016/j.celrep.2019.04.008 |
| WDR33 | elevation | - | U2OS | export | CPA | 10.1016/j.celrep.2019.04.008 |
| RNMT | elevation | reduction | U2OS, AMLp | - | Capping | 10.1073/pnas.2002360117 |
| RNGTT | elevation | reduction | U2OS, AMLp | - | Capping | 10.1073/pnas.2002360117 |
| RAM | elevation | reduction | U2OS | - | Capping | 10.1073/pnas.2002360117 |
| U2AF1 | elevation | - | U2OS | export | Splicing | 10.15252/embj.2021110496 |
| U2AF2 | elevation | reduction | U2OS, AMLp, NOMO-1 | export, translation | Splicing | 10.15252/embj.2021110496 |
| SF3B1 | elevation | reduction | U2OS, AMLp, NOMO-1 | export, translation | Splicing | 10.15252/embj.2021110496 |
| PRPF6 | elevation | reduction | U2OS, AMLp, NOMO-1 | export | Splicing | 10.15252/embj.2021110496 |
| PRPF8 | elevation | reduction | U2OS, AMLp, NOMO-1 | export, translation | Splicing | 10.15252/embj.2021110496 |
| SNRNP200 | elevation | reduction | U2OS, AMLp, NOMO-1 | export | Splicing | 10.15252/embj.2021110496 |
| PRPF19 | elevation | reduction | U2OS, AMLp, NOMO-1 | - | Splicing | 10.15252/embj.2021110496 |
| PRPF31 | elevation | - | U2OS | export | Splicing | 10.15252/embj.2021110496 |
This list is not exhaustive and thus the absence of factors here should not be interpreted as factors not binding. Dashes indicate unknown mechanism. Other mechanisms than those listed could also influence the factors’ production. AMLp refers to primary AML patient specimen; MEFS to mouse embryonic fibroblasts.