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. Author manuscript; available in PMC: 2024 Jun 18.
Published in final edited form as: J Alzheimers Dis. 2021;81(2):607–617. doi: 10.3233/JAD-201580

Table 4.

Behavioral, cognitive, and functional changes due to social isolation among people with dementia according to severity

Dementia severity Adjusted p
Mild
N = 1611
Moderate
N = 741
Severe
N = 861
Sadder
 No 84 (53%) 42 (58%) 43 (50%)
 Partially 27 (17%) 11 (15%) 11 (13%) 0.566
 Yes 48 (30%) 20 (27%) 32 (37%)
Loner
 No 116 (73%) 55 (75%) 65 (76%)
 Partially 18 (11%) 7 (9.6%) 5 (5.8%) 0.731
 Yes 25 (16%) 11 (15%) 16 (19%)
More anxious
 No 75 (47%) 32 (44%) 50 (59%)
 Partially 31 (19%) 5 (6.9%) 4 (4.7%) 0.007
 Yes 54 (34%) 35 (49%) 31 (36%)
More agitated
 No 115 (72%) 49 (67%) 50 (58%)
 Partially 18 (11%) 7 (9.6%) 6 (7.0%) 0.055
 Yes 27 (17%) 17 (23%) 30 (35%)
More aggressive
 No 126 (79%) 49 (67%) 53 (62%)
 Partially 13 (8.1%) 10 (14%) 14 (16%) 0.373
 Yes 21 (13%) 14 (19%) 19 (22%)
Delusion
 No 138 (86%) 48 (65%) 62 (72%)
 Partially 6 (3.7%) 4 (5.4%) 2 (2.3%) 0.003
 Yes 17 (11%) 22 (30%) 22 (26%)
Obsessive-compulsive behavior
 No 137 (86%) 43 (59%) 67 (79%)
 Partially 6 (3.8%) 4 (5.5%) 3 (3.5%) < 0.001
 Yes 17 (11%) 26 (36%) 15 (18%)
Hallucinations
 No 143 (89%) 54 (74%) 61 (71%)
 Partially 3 (1.9%) 2 (2.7%) 6 (7.0%) 0.009
 Yes 15 (9.3%) 17 (23%) 19 (22%)
Forgetting more
 No 64 (40%) 21 (30%) 32 (38%)
 Partially 25 (16%) 2 (2.8%) 2 (2.4%) 0.002
 Yes 71 (44%) 48 (68%) 51 (60%)
Appetite change
 No 101 (63%) 39 (54%) 52 (60%)
 Partially 12 (7.5%) 0 (0%) 1 (1.2%) 0.006
 Yes 47 (29.0%) 33 (46.0%) 33 (38.0%)
Impaired activities of daily living
 No 132 (82%) 37 (51%) 39 (46%)
 Partially 13 (8.1%) 3 (4.2%) 3 (3.5%) < 0.001
 Yes 16 (9.9%) 32 (44.0%) 43 (51.0%)
Sleep difficulty
 No 116 (72%) 49 (67%) 58 (67%)
 Partially 12 (7.5%) 3 (4.1%) 7 (8.1%) 0.759
 Yes 32 (20%) 21 (29%) 21 (24%)
1

n (%); 2Pearson’s Chi-squared test; Fisher’s exact test. All p-values were adjusted by the Benjamini– Hochberg method.