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[Preprint]. 2024 Jun 3:2024.05.31.596892. [Version 1] doi: 10.1101/2024.05.31.596892

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Figure 6. — Characterization of systemic complement activity in mice infected with SARS2-N501Y_MA30. (A and B) Serum C3 and C4 ELISA from control (blue) and infected (red) mice on 2 and 4 dpi. (C) Serum CH₅₀ activity assay from control (blue) and SARS2-N501Y_MA30 mice (red). Comparison of sex difference by serum ELISA for C3 (D) and C4 (E) on 2 and 4 dpi, with data from sex specific CH₅₀ activity assay shown in (F). dpi = days post-infection. Significance determined by one-way ANOVA or unpaired t-test, * p<0.05, ** p<0.001, **** p<0.00001. ns = nonsignificant. C3 and C4 measured from n = 7. DMEM and n = 10 SARS2-N501Y_MA30 mice per group. CH₅₀ assay from n = 10 mice per group, samples run in duplicate.