Figure 4.

The interaction between APOE⁺ macrophage and CD8⁺ Tex cells affects ICI response in TNBC. a) Cell‐cell interactions among immune cell types. b) Cell–cell interactions among APOE⁺ macrophages and different CD8⁺ T cells. c) The relationship between differential outgoing interactions and incoming interaction strength for CD8⁺ T cells and APOE⁺ macrophages. d) Immune‐related ligands and receptors for signal communication between APOE⁺ macrophages and distinct CD8⁺ T cell subsets. e) Color‐coded UMAP plot of responders and non‐responders in CD8⁺ Tex cells. f) Exhausted score of CD8⁺ Tex cells in UMAP. g) The Exhausted.score of CD8⁺ Tex cells between ICI responders and non‐responders. h) Correlation of Exhausted.score with APOE.score in TNBC from GEO and TCGA cohorts. i) OS analysis of distinct Exhausted.score and APOE.score in TNBC from TCGA cohort. ICI: immune checkpoint inhibitor; UMAP: uniform Manifold Approximation and Projection; TNBC: triple negative breast cancer; GEO: Gene Expression Omnibus; TCGA: The Cancer Genome Atlas; OS: overall survival.