Figure 6.

APOE inhibitors can enhance the efficacy of ICI therapy. a) In vivo experimental procedure in mice. b) Results of live imaging of G1–G4 mice. c) Comparison of fluorescence intensity in live imaging of G1–G4 mice. d) Changes in tumor volume of G1–G4 mice after treatment. e) Comparison of tumor weight in G1–G4 mice after four times treatment. f–i) Spatial mIHC staining of G1–G4 mice breast cancer sections (DAPI, F4/80, APOE, CD8, and PD1). j–m) The distance of APOE⁺ macrophages and CD8⁺ Tex cells in G1‐G4 mice. ICI: immune checkpoint inhibitor; mIHC: multiplex immunohistochemistry.