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. 2024 Apr 4;11(23):2305484. doi: 10.1002/advs.202305484

Figure 3.

Figure 3

IL‐NPs dramatically enhance delivery to the brain in vivo and influence regional abacavir accumulation. A–D) Sprague‐Dawley rat brain cross‐sections shown after treatment with: (A) Saline, (B) Bare PLGA NPs loaded with DiD (purple), or (C) IL‐coated PLGA NPs loaded with DiD. Scale bar = 1 mm. (D) Signal quantified by densitometry (area × mean intensity; n = 1/group). E) Biodistribution (%) of injected DiD in isolated organs (% ID organ, n = 3/group; mean ± SEM). † denotes significant difference from respective PLGA‐DiD‐treated group; p < 0.05 (paired two‐tailed t‐test for means). F,G) Representative differences, by 1H‐NMR spectroscopy, in abacavir (ABC) regional brain accumulation in Sprague‐Dawley rat brains (n = 3/group) post intra‐carotid injection for (F) empty IL‐PLGA NPs and (G) IL‐PLGA NPs loaded with ABC. Key proton peak for ABC presence at 8.1 ppm is indicated (see red box, panel G).