FIG. 1.

Mutagenesis of α-helix 2 of the gp41 CT. A linear representation of the gp41 CT is shown at the top; the shaded area represents the membrane-spanning domain of gp41 (MSD). Two predicted helical domains within the CT (α-helix 1 and 2) and gp41 amino acid positions are indicated. The wt sequence is shown; residues which could form a Leu zipper are boxed. Below the wt sequence are indicated the positions of the α-helix 2 mutations. Dashes denote amino acid identity with wt; dots represent deleted residues.