Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Working models propose CD8 T cells mediate the apoptosis of endothelial cells, which leads to the rarefaction of PTCs and renal fibrosis after AKI. We demonstrated that CD8 T cells were recruited by macrophages through Cxcl16-Cxcr6 signaling. CD8 T cluster originated from the proliferating T cluster and induced apoptosis of endothelial cells through Fasl-Fas signaling after AKI, eventually leading to the rarefaction of PTCs and renal fibrosis.
