Fig. 4. (left) Distribution of doubled resonances (in purple) indicating slow exchange of two conformational ensembles mapped on the CYP17A1/abiraterone X-ray structure (3RUK). The F–G loop and K′ helix shown in orange show intermediate exchange, as evidenced by significant broadening of resonances. (right) Examples of doubling of correlations in 1H, 15N-TROSY HSQC spectrum of CYP17A1/abiraterone, Asp 139 (C–D loop), Ser 187 (E–F loop) and Trp 499 (β5 strand).
