Fig. 5. (left) Conformational exchange detected in 15N-edited NOESY of CYP17A1/abiraterone for Gly 138 (C–D loop). Autocorrelation peaks for G138 and G138′ are indicated, as are exchange cross peaks. (right) Collapse of states observed in CYP17A1/abiraterone 1H, 15N-TROSY HSQC for Gly 138 in the absence of cytb5 (blue) to a single conformation (red) upon addition of 0.4 equivalents of cytb5.
