Table 1. Upregulated genes (top 40) by statin (A) and methyl-β-cyclodextrin (MCD) (B).
RNA-seq was performed in statin- or MCD-treated macrophages. For genes upregulated (log2 >1) (Supplementary file 1), the top 40 upregulated genes by both statin and by MCD.
| Gene names | log2 fold change | p value | padj |
|---|---|---|---|
| Pgf | 10.13651906 | 8.87E−12 | 1.50E−10 |
| Rab15 | 9.393223225 | 4.73E−10 | 6.56E−09 |
| Sphk1 | 8.930573917 | 1.11E−09 | 1.45E−08 |
| Cplx2 | 8.774337587 | 1.02E−08 | 1.15E−07 |
| Edn1 | 8.701794125 | 4.44E−10 | 6.21E−09 |
| Dok7 | 8.435798979 | 0.000000194 | 1.79E−06 |
| Pdcd1 | 7.677598898 | 0.00000317 | 0.000023229 |
| Bdkrb2 | 7.485212923 | 0.00000921 | 0.000061728 |
| Pdpn | 7.245557725 | 8.11E−10 | 1.09E−08 |
| Nr4a3 | 6.905154247 | 8.81E−17 | 2.79E−15 |
| Dusp8 | 6.790646438 | 4.60E−46 | 1.27E−43 |
| Areg | 6.694617375 | 9.88E−11 | 1.48E−09 |
| Gm13889 | 6.67201557 | 1.19E−33 | 1.55E−31 |
| Ptpn14 | 6.580623988 | 9.83E−13 | 1.91E−11 |
| Hgfac | 6.329990066 | 0.0000575 | 0.00031881 |
| Clec4n | 6.157949617 | 1.52E−114 | 4.62E−111 |
| Mylk2 | 6.131939756 | 0.00163753 | 0.0060117 |
| Socs2 | 6.088256349 | 0.00180709 | 0.00656174 |
| Hr | 6.018030298 | 8.71E−42 | 2.08E−39 |
| Arntl2 | 6.016235026 | 0.00019782 | 0.00095687 |
| Esyt3 | 6.006389797 | 0.00297479 | 0.01010416 |
| Arhgef26 | 5.979707067 | 0.00654321 | 0.01983335 |
| Itgb3 | 5.924269828 | 0.00404747 | 0.01320581 |
| Tnfrsf9 | 5.761582722 | 2.79E−09 | 3.42E−08 |
| Hbegf | 5.737032919 | 1.23E−16 | 3.81E−15 |
| Sema7a | 5.586005669 | 0.00826075 | 0.02417248 |
| Lrrc32 | 5.473546382 | 0.00000044 | 3.80E−06 |
| Scn11a | 5.408935346 | 0.01371225 | 0.03712608 |
| \Prss35 | 5.402316379 | 0.01365624 | 0.0370148 |
| Mustn1 | 5.257604938 | 0.000000142 | 1.35E−06 |
| Rgs16 | 5.190735177 | 0.000000529 | 0.000004505 |
| Clcf1 | 5.151265251 | 0.00361481 | 0.01196418 |
| BC021614 | 5.075557852 | 0.00411785 | 0.01339593 |
| Cxcl2 | 5.021314952 | 9.02E−191 | 1.10E−186 |
| Fam20a | 4.966798875 | 0.00741 | 0.02203267 |
| Sp7 | 4.928788817 | 0.00615636 | 0.01883905 |
| Gprc5a | 4.927629461 | 6.27E−19 | 2.49E−17 |
| Nfe2 | 4.875385857 | 1.23E−14 | 3.03E−13 |
| Ccl3 | 4.847246887 | 1.61E−119 | 6.54E−116 |
| Lamc2 | 4.837832794 | 1.68E−09 | 2.13E−08 |
| Il1b | 4.115965111 | 6.22E−29 | 1.71E−26 |
| Cxcl2 | 3.962459756 | 0 | 0 |
| Egr1 | 3.365911716 | 2.49E−125 | 2.10E−122 |
| Tnf | 3.306387647 | 1.50E−176 | 2.06E−173 |
| Nfkbiz | 3.259909052 | 0 | 0 |
| Arc | 3.021670065 | 2.13E−30 | 6.18E−28 |
| Ier3 | 2.897093474 | 4.02E−153 | 4.43E−150 |
| Zfp36 | 2.853262721 | 1.29E−157 | 1.57E−154 |
| Lif | 2.748205257 | 1.80E−10 | 2.18E−08 |
| Dusp2 | 2.627829764 | 7.14E−129 | 6.55E−126 |
| Tnfaip3 | 2.585932017 | 2.15E−279 | 7.87E−276 |
| Egr2 | 2.32626986 | 2.58E−46 | 9.46E−44 |
| Ier2 | 2.034656801 | 2.63E−262 | 7.24E−259 |
| Dusp1 | 1.977596852 | 6.88E−109 | 4.45E−106 |
| Junb | 1.950358114 | 5.59E−74 | 2.80E−71 |
| Btg2 | 1.92138967 | 3.61E−204 | 7.94E−201 |
| Pde4b | 1.920348453 | 8.18E−87 | 4.50E−84 |
| Dusp5 | 1.918194267 | 6.50E−27 | 1.75E−24 |
| Maff | 1.891310296 | 8.36E−41 | 2.70E−38 |
| Ppp1r15a | 1.878276549 | 6.16E−121 | 4.84E−118 |
| Ptgs2 | 1.775605515 | 1.44E−201 | 2.63E−198 |
| Phlda1 | 1.775056479 | 1.24E−13 | 1.90E−11 |
| Nfkbid | 1.673557595 | 4.68E−111 | 3.22E−108 |
| Fos | 1.629250783 | 1.79E−146 | 1.79E−143 |
| Nfkbia | 1.595064568 | 7.69E−196 | 1.21E−192 |
| Nr4a1 | 1.580570737 | 3.42E−42 | 1.18E−39 |
| Socs3 | 1.571871776 | 9.72E−66 | 4.11E−63 |
| Gdf15 | 1.555447107 | 0.0000514 | 0.00317852 |
| Pim1 | 1.547649464 | 5.43E−108 | 3.32E−105 |
| Zc3h12a | 1.524253928 | 7.40E−92 | 4.28E−89 |
| Egr3 | 1.494163502 | 5.44E−20 | 1.13E−17 |
| Osm | 1.430409511 | 1.27E−22 | 3.10E−20 |
| Myc | 1.331901297 | 1.10E−10 | 1.35E−08 |
| Gpr84 | 1.310067562 | 1.23E−18 | 2.42E−16 |
| Traf1 | 1.30684728 | 4.76E−52 | 1.81E−49 |
| Cxcl10 | 1.28466895 | 1.01E−15 | 1.76E−13 |
| Hmgcs1 | 1.279756645 | 7.39E−07 | 6.25E−05 |
| Errfi1 | 1.254057102 | 1.47E−38 | 4.63E−36 |
| H2-K2 | 1.251411578 | 1.71E−17 | 3.24E−15 |
| Ccrl2 | 1.214065207 | 1.41E−13 | 2.13E−11 |