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. 2024 Jun 19;12(12):e16113. doi: 10.14814/phy2.16113

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© 2024 The Author(s). Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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The conducted responses elicited by high contraction frequency was significantly blunted by the presence of pannexin inhibitor mefloquine and purinergic receptor blocker suramin. The change in diameter in of the 4A arteriole in response to capillary stimulation with high contraction frequency (60 CPM(20 Hz)) in the absence () and presence () of (a) MEF (b) SUR and (c) HALO. Both MEF treatment (F (1, 28) = 5.4; p _treatment = 0.027, p _time <0.0001, p _interaction = 0.041) and SUR treatment (F (1, 14) = 27.5; p _treatment = 0.0001, p _time <0.0001, p _interaction = 0.0003) significantly impacted the vasodilation induced at 60CPM and *indicates a significant difference between the contraction response in the absence and presence of the blocker. HALO treatment did not significantly inhibit the vasodilation induced by 60CPM muscle contraction (F (1, 16) = 1.8; p _treatment = 0.20, p _time <0.0001, p _interaction = 0.17). Data are shown as mean ± SD and analyzed by a two‐way repeated measures ANOVA with Fisher's LSD post hoc test where applicable. F statistics are reported with degrees of freedom for the numerator and the denominator (F [DFn, DFd]).

Inline graphic — The conducted responses elicited by high contraction frequency was significantly blunted by the presence of pannexin inhibitor mefloquine and purinergic receptor blocker suramin. The change in diameter in of the 4A arteriole in response to capillary stimulation with high contraction frequency (60 CPM(20 Hz)) in the absence () and presence () of (a) MEF (b) SUR and (c) HALO. Both MEF treatment (F (1, 28) = 5.4; p _treatment = 0.027, p _time <0.0001, p _interaction = 0.041) and SUR treatment (F (1, 14) = 27.5; p _treatment = 0.0001, p _time <0.0001, p _interaction = 0.0003) significantly impacted the vasodilation induced at 60CPM and *indicates a significant difference between the contraction response in the absence and presence of the blocker. HALO treatment did not significantly inhibit the vasodilation induced by 60CPM muscle contraction (F (1, 16) = 1.8; p _treatment = 0.20, p _time <0.0001, p _interaction = 0.17). Data are shown as mean ± SD and analyzed by a two‐way repeated measures ANOVA with Fisher's LSD post hoc test where applicable. F statistics are reported with degrees of freedom for the numerator and the denominator (F [DFn, DFd]).