Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Jun 19;12(12):e16113. doi: 10.14814/phy2.16113

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2024 The Author(s). Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

The conducted responses elicited by low stimulus frequency was significantly blunted by the presence of pannexin inhibitor mefloquine. The change in diameter of the 4A arteriole in response to capillary stimulation with low stimulus frequency (4 Hz [15CPM]) in the absence () and presence () of (a) MEF (b) SUR and (c) HALO. MEF treatment (F (1, 12) = 9.4; p _treatment = 0.0097, p _time = 0.016, p _interaction < 0.0001) significantly impacted the vasodilation induced at 4 Hz and * indicates a significant difference between the contraction response in the absence and presence of the blocker. Both SUR treatment (F (1, 24) = 0.36; p _treatment = 0.56, p _time < 0.0001, p _interaction = 0.016) and HALO treatment did not significantly inhibit the vasodilation induced by 4 Hz muscle contraction (F (1, 16) = 0.27; p _treatment = 0.61, p _time < 0.0001, p _interaction = 0.53). *indicates a significant difference between the contraction response in the absence and presence of the blocker. Data are shown as mean ± SD and analyzed by a two‐way repeated measures ANOVA with Fisher's LSD post hoc test where applicable. F statistics are reported with degrees of freedom for the numerator and the denominator (F [DFn, DFd]).

Inline graphic — The conducted responses elicited by low stimulus frequency was significantly blunted by the presence of pannexin inhibitor mefloquine. The change in diameter of the 4A arteriole in response to capillary stimulation with low stimulus frequency (4 Hz [15CPM]) in the absence () and presence () of (a) MEF (b) SUR and (c) HALO. MEF treatment (F (1, 12) = 9.4; p _treatment = 0.0097, p _time = 0.016, p _interaction < 0.0001) significantly impacted the vasodilation induced at 4 Hz and * indicates a significant difference between the contraction response in the absence and presence of the blocker. Both SUR treatment (F (1, 24) = 0.36; p _treatment = 0.56, p _time < 0.0001, p _interaction = 0.016) and HALO treatment did not significantly inhibit the vasodilation induced by 4 Hz muscle contraction (F (1, 16) = 0.27; p _treatment = 0.61, p _time < 0.0001, p _interaction = 0.53). *indicates a significant difference between the contraction response in the absence and presence of the blocker. Data are shown as mean ± SD and analyzed by a two‐way repeated measures ANOVA with Fisher's LSD post hoc test where applicable. F statistics are reported with degrees of freedom for the numerator and the denominator (F [DFn, DFd]).