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. 2024 Jun 19;12(12):e16113. doi: 10.14814/phy2.16113

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© 2024 The Author(s). Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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The conducted responses elicited by high contraction frequency was not significantly blunted by any of the tested antagonists. The change in diameter of the 4A arteriole in response to capillary stimulation with high stimulus frequency (40 Hz(15CPM)) in the absence () and presence () of (a) MEF (b) SUR and (c) HALO. Neither MEF treatment (F (1, 11) = 0.06; p _treatment = 0.82, p _time = 0.008, p _interaction = 0.98), SUR treatment (F (1, 23) = 1.73; p _treatment = 0.20, p _time < 0.0001, p _interaction = 0.076) or HALO treatment significantly impacted the vasodilation induced by 40 Hz muscle contraction (F (1, 16)=2.53; p _treatment = 0.13, p _time < 0.0001, p _interaction = 0.73). Data are shown as mean ± SD and analyzed by a two‐way repeated measures ANOVA with Fisher's LSD post hoc test where applicable. F statistics are reported with degrees of freedom for the numerator and the denominator (F [DFn, DFd]).

Inline graphic — The conducted responses elicited by high contraction frequency was not significantly blunted by any of the tested antagonists. The change in diameter of the 4A arteriole in response to capillary stimulation with high stimulus frequency (40 Hz(15CPM)) in the absence () and presence () of (a) MEF (b) SUR and (c) HALO. Neither MEF treatment (F (1, 11) = 0.06; p _treatment = 0.82, p _time = 0.008, p _interaction = 0.98), SUR treatment (F (1, 23) = 1.73; p _treatment = 0.20, p _time < 0.0001, p _interaction = 0.076) or HALO treatment significantly impacted the vasodilation induced by 40 Hz muscle contraction (F (1, 16)=2.53; p _treatment = 0.13, p _time < 0.0001, p _interaction = 0.73). Data are shown as mean ± SD and analyzed by a two‐way repeated measures ANOVA with Fisher's LSD post hoc test where applicable. F statistics are reported with degrees of freedom for the numerator and the denominator (F [DFn, DFd]).