TABLE 5.

PanX/Pur and GJ signaling pathways contribute to contraction‐induced upstream conducted vasodilation from capillaries to arterioles. Results summarizing the affect (✓) or lack thereof (✗) of PanX/Pur or GJ antagonists on upstream arteriole conducted vasodilation elicited by various muscle contraction parameters at the capillary level.

Pathway	Drug	6CPM (20 Hz)	60CPM (20 Hz)	4 Hz (15CPM)	40 Hz (15CPM)
PanX/Pur	MEF	✗	✓	✓	✗
PanX/Pur	SUR	✗	✓	✗	✗
GJ	HALO	✓	✗	✗	✗
PanX/Pur + GJ	SUR + HALO	‐	‐	‐	✗

Note: ✗, Indicates the drug did not significantly affect the conducted response; ✓, Indicates the drug significantly affected the conducted response; ‐ Indicates drugs not tested.