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. 2024 May 22;630(8017):762–768. doi: 10.1038/s41586-024-07475-0

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 4 — a, Structures of GluK2_{Glu-2xConA-BPAM}, GluK2_{Glu-1xConA-BPAM}, GluK2_Glu-4fold and GluK2_Glu-asym viewed parallel to the membrane (top) and their LBD layers viewed extracellularly (bottom). Subunits A/C colored orange, B/D cyan, and ConA molecules purple and magenta. Molecules of Glu (dark green) and BPAM (dark blue) are shown as space-filling models. Carbohydrates (light green) and lipids (violet) are shown as sticks. The distances between the centers of mass of ATD and LBD layers are indicated. b-f, ATD layer structures from GluK2_BPAM (b, PDB ID: 8FWS, blue), GluK2_{Glu-ConA-BPAM} (c, pink), GluK2_Glu-4fold (d, smudge), GluK2_Glu-asym (e, green) and their superposition (f). g-j, Individual LBD structures from GluK2_{Glu-ConA-BPAM} (g, pink), GluK2_Glu-4fold (h, smudge), GluK2_Glu-asym (i, green) and their superposition (j).