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. 2024 May 22;630(8017):762–768. doi: 10.1038/s41586-024-07475-0

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 5 — a-d, Structures of GluK2_Glu-4fold (a, green), GluK2 in complex with (2 S,4 R)-4-methylglutamate (SYM) in the putative desensitized state (b, GluK2_SYM, PDB ID: 5KUF, cyan), GluK2 in the putative apo state (c, GluK2_apo, PDB ID: 8F0O, orange) and their superposition (d) viewed parallel to the membrane. The agonist molecules Glu and SYM are shown as space-filling models. e-h, LBD tetramers in GluK2_Glu-4fold (e), GluK2_SYM (f), GluK2_apo (g) and their superposition (h) viewed extracellularly. i-l, Individual LBDs from GluK2_Glu-4fold (i), GluK2_SYM (j), GluK2_apo (k) and their superposition (l).