FAP	AFAP/HFAS	HNPCC/Lynch	UCAN
Mean age at diagnosis ofcolorectal cancer	32-39	45-55	42-49	40-70
Distribution of cancer	Random	Mainly right colon	Mainly right colon	Mainly left colon
No of polyps	>100	1-100	1 (ie tumour)
Sex ratio (male:female)	1:1	1:1	1.5:1	1:1
Endoscopic view of polyp	Pedunculated	Mainly flat	Pedunculated (45%); flat (55%)	None
Lag time (years) from early adenoma to occurrence of cancer	10-20	10	5	?<8
Proportion (%) of colonic cancer	1	0.5	1-5	<0.5
Superficial physical stigmata	80% have retinal pigmentation	None	Only in Muir-Torre syndrome	None
Distribution of polyps	Distal colon or universal	Mainly proximal to splenic flexure with rectal sparing	Mainly proximal to splenic flexure	None
Carcinoma histology	More exophytic growth	Non-exophytic but very variable	Inflammation increased mucin	Mucosal ulceration and inflammation
Other associated tumours	Duodenal adenoma cerebral and thyroid tumours, medulloblastoma and desmoids	Duodenal adenoma	Endometrial ovarian, gastric cancer, glioblastoma, many other cancers
Gene (chromosome) mutation	APC (5q 21) distal to 5′	APC (5q 21) proximal to 5′	MHS2 (2p), MLH1 (3p21), PMS1 (2q31), PMS2 (7p22)	Multiple mutations, 17p (p53), 5q (APC), 9p (p16)