. 2024 May 21;40(3):361–375. doi: 10.1007/s43188-024-00243-2

Table 2.

Summary of acute toxicity studies of cocamidopropyl betaine (CAPB)

Subjects	Route	Dose	Results	Refs.
Mouse/CFR (10/group)	Oral intubation	30% active CAPB	LD₅₀ = 6.90 g/kg	[4]
Rat/Wistar (5 females and 5 males/group)	Oral gavage	5.00, 6.30, 7.94, 10.00 mL/kg of CAPB (30% active, pH 5.5)	LD₅₀ = 7.97 g/kg	[5]
Rat/Albino (5/group)	Oral gavage	2.0, 4.0, 5.0, 6.3, 8.0, 16.0 g/kg of 30% active CAPB	LD₅₀ = 4.9 g/kg	[6]
Rat/Wistar (5 females and 5 males/group)	Oral gavage	2.0, 2.71, 3.68, 5.0, 6.78 g/kg of 30% active CAPB	LD₅₀ = 4.91 g/kg	[7]
Rat/Sprague‒Dawley (5 females and 5 males/group)	Oral gavage	35.61% active CAPB	LD₅₀ > 1.8 g/kg (male)	[8]
Rat/CD (5 females and 5 males/group)	Oral gavage	5.0 g/kg of 31% active CAPB	LD₅₀ > 5.0 g/kg	[8]
Rat/Wistar (5/group)	Oral gavage	4.0, 8.0, 10.0, 12.5, 16.0, 32.0 g/kg of 30% active CAPB	LD₅₀ = 8.55 g/kg	[8]
Rat/CD (5 females and 5 males/group)	Dermal	2.0 g/kg of 31% active CAPB	LD₅₀ > 2.0 g/kg	[8]