Table 7.

Summary of genotoxicity studies of cocamidopropyl betaine (CAPB)

Assay	Concentration	Results	Refs.
Bacterial Assays using S. typhimurium strains TA98, TA100, TA1535, TA1537, TA1538	0.004, 0.02, 0.1, 0.2, 0.4 μL/plate CAPB (31.0% active)	Negative (with or without metabolic activation)	[28]
Bacterial Assays using S. typhimurium strains TA1535, TA1537, TA1538, TA98, TA100	0.001 and 0.300 μL/plate CAPB (30% active)	Negative (with or without metabolic activation)	[29]
Bacterial Assays using S. typhimurium strains TA98, TA1535, TA1537, TA1538	0, 50, 150, 500, 1500, or 5000 μg/plate CAPB (28.5–30.5% active)	Negative (with or without metabolic activation)	[8]
Bacterial Assays using S. typhimurium strains TA1535, TA1537, TA1538, TA98, TA100	1, 4, 16, 64, 256 μg/plate without S-9 activation and at 4, 16, 64, 256, 1024 μg/plate with S-9 activation	Negative (with or without metabolic activation)	[8]
Mammalian Cell Assays using L5178Y TK ± mouse lymphoma assay	0.001, 0.01, 0.1, 1.0, 10, and 100 μL/mL CAPB (30.9% active)	Negative	[30]
Mouse micronucleus test	0.02 or 0.2 g/kg CAPB intraperitoneal injection	Negative	[9]

S. typhimurium: Salmonella typhimurium