Table 8.

Systemic exposure doses (SEDs) of cocamidopropyl betaine for dermal application

Category of product	Product	Maximum concentration (%)	Estimated daily exposure to a cosmetic product (mg/kg/day)	SED (mg/kg/day)
Rinse off skin & hair	Shower gel	30.01)	2.79a)	0.41850
	Shower milk	30.01)	2.79a)	0.41850
	Hand wash soap	30.01)	3.33a)	0.49950
	Hand cleansing liquid soap	30.01)	3.33a)	0.49950
	Solid soap	30.01)	3.33a)	0.49950
	Liquid soap	30.01)	3.33a)	0.49950
	Shampoo	30.01)	1.51b)	0.22650
	Hair conditioner	30.01)	0.67a)	0.10050
	Hair mask	30.01)	0.78b)	0.11700
	Mask	30.01)	0.25c)	0.03750
	Cleansing milk	30.01)	7.34c)	1.10100
	Cleansing gel	30.01)	7.34c)	1.10100
	Exfoliating scrub	30.01)	0.37c)	0.05550
Leave-on skin & hair	Hair oil	9.02)	0.95b)	0.04275
	Hair styling products	9.02)	5.74a)	0.25830
	Styling gel	9.02)	4.64b)	0.20880
	Styling foam	9.02)	20.71b)	0.93195
	Serum	6.03)	11.63c)	0.34890
Facial make-up	Prime face	6.03)	13.52c)	0.40560
Eye make-up	Eyeliner	3.04)	0.08a)	0.00120
	Brow liner	3.04)	0.08c)	0.00120
Make-up remover	Make-up remover	30.01)	8.33a)	1.24950
Deodorant	Nonspray	2.05)	22.08a)	0.22080

¹⁾Concentration reported in China: Rinse-off products

- Concentration reported in FDA VCRP: ²⁾Hair noncoloring, ³⁾Leave-on products, ⁴⁾Eye area, ⁵⁾Deodorant (Underarm)

^a)reference[33]

^b)reference[34]

^c)reference[35]