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. 2024 Apr 26;73(7):1076–1086. doi: 10.1136/gutjnl-2023-331743

Figure 1.

Figure 1

The Histologically Active EoE Diagnostic Panel (HAEDP) differentiates patients with histologically active eosinophilic oesophagitis (EoE) from patients with EoE in remission and control individuals. (A) Principal component analysis visualises the geometric distance between samples. Each dot corresponds to a patient sample. (B) Graphical representation of the differentially expressed genes in the analysis comparing (a) controls with EoE AF−, (b) EoE RF− with EoE AF− and (c) EoE RF+ with EoE AF+ (adjusted p≤0.05). (C) Venn diagrams of downregulated (log2FC ≤−2) and upregulated (log2FC ≥2) genes differentially expressed in histologically active EoE compared with controls and EoE in histological remission. Intersections of both Venn diagrams correspond to the HAEDP (controls n=5, EoE AF(+) n=5, EoE AF(−) n=5, EoE RF(+) n=4, EoE RF(−) n=5). FC, fold change.