Figure 2.

The Histologically Active EoE Diagnostic Panel (HAEDP) assesses disease severity in patients with histologically active eosinophilic oesophagitis (EoE). (A) Principal component analysis visualises the geometric distance between samples after applying the HAEDP gene list. Each dot corresponds to a patient. (B) The overall disease activity score assessed by the physician was determined for the EoE1 and EoE2 subgroups (*p≤0.05 using non-parametric t-test analysis). Hierarchical heatmaps of 46 upregulated (C) and 7 downregulated (D) genes of HAEDP in patients with histologically active EoE samples. Each column represents a patient, and each row represents a gene. Hierarchical clustering was used to analyse the data, and distance methods were set as ‘Euclidean’ (controls n=5, EoE AF(+) n=5, EoE AF(−) n=5, EoE RF(+) n=4, EoE RF(−) n=5).