Figure 5.

Combined EoE Diagnostic Panel (EDP) and Histologically Active EoE Diagnostic Panel (HAEDP) detect conventional eosinophilic oesophagitis (EoE) among EoE variants. Hierarchical heatmap of genes of the EDP and HAEDP applied on the RNA-sequencing dataset from Greuter et al ¹⁴: (A) upregulated genes and (B) downregulated genes (C) principal component analysis after applying HAEP and EDP panels to visualise the distribution of the samples. (D) List of genes upregulated only in conventional EoE as compared with other EoE variants and control. Data are the normalised counts mean±SEM. *P≤0.001 using one-way analysis of variance test followed by Holm-Šídák’s multiple comparisons test (controls n=7, conventional EoE n=10, GERD n=6, EoE-like disease n=13, lymphocytic EoE n=5, non-specific EoE n=10).