Figure 1 .
The structural assembly of pMHC-TCR-CD3 complex and TCR signaling cascade
The fully assembled pMHC-TCR-CD3 complex has been solved. CD8 binds to the pMHC and recruits LCK to phosphorylate CD3 and initiate TCR downstream signaling cascade.
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.