Fig. 1.

Epidemiological and Clinical Characteristics of CHIKV Infections in Ribeirão Preto, São Paulo, Brazil. A) Annual distribution of reported CHIKV and DENV cases in Ribeirão Preto from 2016 to 2023. B) Distribution of CHIKV-positive cases, highlighting the notable increase in CHIKV cases in 2023, with 75 % autochthonous. C) Comparative analysis of leukocyte counts in CHIKV-positive individuals versus healthy controls, indicating significant leukopenia (P < 0.0001). D) Comparative analysis of platelet counts in CHIKV-positive individuals versus healthy controls, showing significant thrombocytopenia (P = 0.0003). E) Phylogenetic tree of CHIKV sequences from Ribeirão Preto, clustering with the ECSA genotype reference strains from Brazilian and South American isolates. The red dots represent the 14 complete genomes sequenced in this study.