Table 1. Comparison of complete blood count and serum biochemical markers in bitches with mammary gland tumors, before (day 0) and at the end of treatment with sodium dichloroacetate (DCA) (day 15) (n=19).
| Parameter | Values before DCA treatment (day 0) n=19 | Values after DCA treatment (day 0) n=19 | P |
|---|---|---|---|
| Mean (SD) | Mean (SD) | ||
| Erythrocytes (106/µL) | 6.9 (± 0.9) | 6.4 (± 0.9) | 0.08 |
| Hemoglobin (g/dL) | 16.7 (± 3.0) | 16.3 (± 2.7) | 0.61 |
| Hematocrit (%) | 47.8 (± 6.3) | 43.6 (± 7.6) | 0.02 |
| Mean corpuscular volume (MCV) (fL) | 70.0 (± 4.1) | 69.8 (± 4.1) | 0.86 |
| Mean corpuscular hemoglobin (MCH) (pg) | 24.4 (± 2.6) | 23.9 (± 2.4) | 0.50 |
| Mean corpuscular hemoglobin concentration (%) | 34.8 (± 2.8) | 34.3 (± 2.9) | 0.53 |
| Total plasma protein (g/dL) | 7.5 (± 0.9) | 7.4 (± 1.0) | 1.00* |
| Platelets (103/µL) | 293.9 (± 97.8) | 310.9 (± 84.5) | 0.50 |
| Leukocytes (103/µL) | 11.7 (± 4.9) | 9.6 (± 4.6) | 0.04* |
| Eosinophils (/µL3) | 676.8 (± 565.3) | 513.6 (± 372.6) | 0.21* |
| Lymphocytes (/µL) | 1,994.3 (± 914.7) | 1,587.9 (± 636.1) | 0.06 |
| Monocytes (/µL) | 658.2 (± 336.4) | 512.5 (± 324.6) | 0.20* |
| Neutrophils (/µL) | 8,369.3 (± 4,439.0) | 6,993.9 (± 4,155.8) | 0.08* |
| Albumin (g/dL) | 3.0 (± 0.3) | 3.0 (± 0.3) | 0.94 |
| Alanine aminotransferase (UI) | 36.9 (± 17.7) | 34.4 (± 12.5) | 0.49 |
| Creatinine (mg/dL) | 1.0 (± 0.2) | 1.0 (± 0.3) | 0.49 |
| Alkaline phosphatase (UI) | 103.1 (± 166.3) | 106.5 (± 161.1) | 0.86* |
| Urea (mg/dL) | 34.4 (± 14.2) | 30.2 (± 11.3) | 0.28 |
*Wilcoxon test for paired samples. Other values were calculated using Student’s t-test for paired samples.