Table 3.
Commonly used prescription medications with known/suspected teratogenic effects during pre-LMP and 1st trimester in MarketScan (2011–2020) and MAX/TAF (2011–2018)
| MarketScan | MAX/TAF | |||
|---|---|---|---|---|
| Medication | Pre-LMP | 1st Trimester | Pre-LMP | 1st Trimester |
|
| ||||
| Cholestyramine | 395 | 250 | 275 | 159 |
| Colchicine | 140 | 68 | 89 | 60 |
| Cyclophosphamide | <11 | <11 | <11 | <11 |
| Danazol | 17 | <11 | 14 | <10 |
| Isotretinoin | 157 | 28 | 50 | 15 |
| Mercaptopurine | 293 | 236 | 102 | 77 |
| Methimazole | 827 | 653 | 1,121 | 962 |
| Methotrexate | 487 | 115 | 366 | 160 |
| Misoprostol | 10,138 | 501 | 3,283 | 236 |
| Propylthiouracil | 623 | 1,470 | 280 | 1,217 |
| Streptomycin sulfate | <11 | 0 | 0 | 0 |
| Tetracycline | 932 | 264 | 420 | 135 |
| Warfarin | 583 | 311 | 775 | 453 |
Counts > 0 or < 11 suppressed. Know/Suspected teratogens with zero exposed: busulfan, chlorambucil, dactinomycin, doxorubicin, thalidomide, vinblastine, and vincristine
LMP: last menstrual period