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Endogenous ligand binding poses of aminergic receptors. A–E) Binding poses of H3R (A), H1R (B), D1R (C), 5‐HT1A (D), and β1AR (E) with its endogenous ligands. F) Superimposition of H3R‐hisatime and H1R‐histamine structures. G,H) Effects of histamine‐induced G‐protein dissociation in HEK293 cells expressing histamine receptor mutants at 5.46 position. Dose‐response curves for H3R E2065.46 mutants (G) and H1R N1965.46E mutant (H) were measured using the NanoBiT assay (n = 3).
