TABLE 1.
General properties of previously characterized HERV families investigated in this study
| Family | Primer | Size (kb) of sequenced region | Copy no.a | Available sequence datab |
|---|---|---|---|---|
| HERV.E | tRNAGlu | 8.8 | 85 | LTR-gag-pol-env-LTR |
| HERV.I | tRNAIle | 9.0 | 85 | LTR-gag-pol-env-LTR |
| HERV.W | tRNATrp | 7.6c | 115 | LTR-gag-pol-env-LTR |
| HERV.H | tRNAHis | 8.7d | 660 | LTR-gag-pol-env-LTR |
| HERV.L | tRNALeu | 6.5 | 575 | LTR-gag-pol-DUT-LTR |
| HERV.K | tRNALys | 9.1 | 170 | LTR-gag-DUT-pol-env-LTR |
| ERV-9 | tRNAArg | 1.8 + 3.8 | 70 | LTR + part gag-pol-Δenv-LTR |
| HERV.HML6 | tRNALys | 7.5e | 45 | LTR-gag-DUT-pol-env-LTR |
| RRHERV.I | tRNAIle | 3.3 | 15 | LTR-Δpol-env-LTR |
| HERV.R | tRNAArg | 5.0f | 15 | LTR + part gag + part pol + env-LTR |
| HERV.P | tRNAPro | 2× 0.6 + 0.4 | 70 | LTR + part pol + LTR |
| HERV.S71 | ? | 5.5 | 15 | gag-Δpol-LTR |
| HERV.XA | ? | 4.7 | 15 | Part pol-Δenv |
| HERV.ADP | ? | 1.5 | 60 | Part pol |
| HERV.FRD | ? | 2.8 | 15 | Part pol |
| HERV.HML5 | ? | 0.25 | 45 | Part pol |
a
Estimated copy number as determined by BLAST search and phylogenetic analysis (i.e., elements which contain domains 1 to 5 of RT, assuming a random distribution of elements within the human genome).
b
part, only part of the gene or region has been sequenced; Δ, entire gene or region has been sequenced but contains obvious deletions.
c
Combined total for nine cDNA clones.
d
env-containing elements.
e
Combined total for three clones.
f
Combined total for five subclones.