TABLE 4.
General properties of partially characterizeda and novel HERV families
| Family | Cosmid | Primer | Size (kb) | Copy no.b | Genomic organization |
|---|---|---|---|---|---|
| Partially characterized | |||||
| HERV.ADP | AC005741 | tRNAThr(?) | 8.4 | 60 | LTR-gag-pol-env-LTR |
| HERV.FRD | AC004022 | tRNAHis | 10.8 | 15 | LTR-ORF?-gag-pol-env-LTR |
| HERV.XA | AC000378 | tRNAPhe | 6.2 | 15 | LTR-gag-Δpol-Δenv-LTR |
| HERV.HML5 | AC004536 | tRNAIle | 7.8 | 45 | LTR-Δgag-DUT-pol-env-LTR |
| Novel | |||||
| HERV.Z69907 | Z69907 | No 5′ LTR | ∼6.6 | 30 | gag-pol-Δ-env-LTR |
| HERV.R (type b) | AC004045(b) | tRNAArg | 8.7 | 15 | LTR-gag-pol-env-LTR |
| HERV.F | Z94277 | tRNAPhe | 8.7 | 15 | LTR-gag-pol-env-LTR |
| HERV.F (type b) | AC002416 | tRNAPhe | 6.8 | 30 | LTR-gag-Δpol-Δenv-LTR |
| HERV.S | AC004385 | tRNASer | 6.7 | 70 | LTR-gag-pol-env-LTR |
| HERV.H49C23 | H49C23 | No LTRs | ∼6.0 | 70 | Δgag-pol-Δenv |
a
Properties of closely related HERV-containing cosmid clones.
b
Number of elements containing domains 1 to 5 of RT, estimated by BLAST search followed by phylogenetic reconstruction.