Table 2.
List of C. parapsilosis mutations
| Genes | Roles | isolates | Protein Mutations |
|---|---|---|---|
| FAS2; CPAR2_807400 | Virulence | S1, S2 | A328V; I330T; S1349N |
| Biofilm Formation | R1, R3, R4 | I330T; S1349N | |
| CPAR2_110220 | Resistance to SRS | S1 | P441T; R478K |
| Virulence | |||
| Resistance to caspofungin | |||
| Resistance to fluconazole | |||
| ERG11, CPAR2_303740 | Resistance to azole | S1, S2 | F132Y; R398I |
| Ergosterol | R1, R2, R3, R4 | F132Y | |
| FKS1, CPAR2_106400 | Resistance to caspofungin | S2 | A1422G; M1499I |
| Biofilm Formation | |||
| UPC2, CPAR2_207280 | Resistance to ketoconazole | R1 | N455R |
| CFEM4, CPAR2_402890 | Biofilm formation | S1, S2, R1, R3, R4 | T99A |
| Virulence | |||
| ATP6; CPAR2_203290 | S1, S2 | A120T | |
| R1 | T191A | ||
| CPAR2_207540 | Resistance to fluconazole | R3, R4 | I489V |
| Virulence | |||
| CDR1; CRAR2_405290 | Resistance to fluconazole | R1 | I1287V, I969T |
| R2 | N1132D | ||
| R3, R4 | I1287V | ||
| ERG4; CPAR2_502980 | Virulence | R1, R3 | P63S |
| Ergosterol | R3 | P63S | |
| ERG6; CPAR2_405010 | Biofilm formation | S1, S2, R1, R2, R3, R4 | S208G; S304G |
| Virulence | |||
| Ergosterol | |||
| UPC2; CPAR2_207280 | Resistance to ketoconazole | R1 | N455D |
| Ergosterol | |||
| STP4; CPAR2_211740 | Resistance to caspofungin | S1, S2, R1, R3, R4 | L195P |
| Resistance to SDS | |||
| CHS1; CPAR2_805640 | Virulence | R1 | P52L |
| MP65; CPAR2_407410 | Adhesion | S1, S2 | F369L |
| Biofilm formation | |||
| Virulence | |||
| SAPP3; CPAR2_102420 | Virulence increased | R1, R3, R4 | T359I |
| GCN4; CPAR2_806570 | Biofilm formation: decreased | S2 | G120D |
| NTC1; CPAR2_803760 | Resistance to caspofungin | S1, S2, R1, R3, R4 | L671Q |
| CHS3; CPAR2_801800 | Virulence | S1, S2, R1, R3, R4 | L38R |
| ALS6; CPAR2_404790 | Adhesion | R1 | S2190T |
| R3, R4 | I1430T, S2190T | ||
| ALS7; CPAR2_404800 | Virulence | R2, R3, R4 | E765D |
| ALS11; CPAR2_404780 | Virulence | S1, S2 | G94E, L350V |
| R1, R3, R4 | L350V, G1000R | ||
| CFEM5; CPAR2_300110 | Biofilm Abnormal | R1, R3 | S224T |
| R4 | G807S, P805L, A803T, G797S, L735P, T733A, G717S, P715L, S224T, P795L, A793T, A783T, S737G | ||
| CPAR2_700020 | S1, S2 | V171I | |
| CDRV CPAR2_700030 | Resistance to fluconazole | R1 | L591I |
| R3, R4 | D127Y | ||
| CPAR2_700100 | Virulence | S1, S2, R1,R3, R4 | F46I |
| CPAR2_700140 | Resistance to caspofungin | R1, R3, R4 | N140S |
| EFG1; CPAR2_701620 | Resistance to SDS | S1, S2, R1, R3, R4 | E452G |
| Resistance to caspofungin | |||
| Virulence | |||
| Biofilm Formation | |||
| SAP7; CPAR2_105640 | Virulence decreased | R1, R3, R4 | Q66H |
| SAP9; CPAR2_102610 | Virulence decreased | R1, R3, R4 | S439G |
| CPAR2_302400 | R3, R4 | I114M | |
| ERG25; CPAR2_801410 | Resistance to fluconazole | R3 | D9N |
| Ergosterol | |||
| HWP1; CPAR2_403520 | Biofilm formation | S1, S2 | L461S |
| Virulence | R1, R4 | G1129E, Q1128P, G1127R, E1126G, S1114G, L1113R P975S, S974G, L973P, L461S, P1115S | |
| R3 | G1129E, Q1128P G1127R, E1126G, L461S | ||
| EPA; FUN31; CPAR2_808450 | Resistance to caspofungin | R1, R3, R4 | D396G |
| EAP1; CPAR2_805000 | Resistance to SDS | R3 | T663S |
| UME6; CPAR2_803820 | Virulence | S1, S2 | C547G, T46A |
| R1, R3, R4 | C547G | ||
| FLO8; CPAR2_601080 | Biofilm formation | S1, S2, R1, R3, R4 | G1052S |
| Virulence |