Table 1.
Characteristics of participants at first post-stroke cognitive assessment, by stroke type.
| Characteristic | Stroke Type (n=1,143) | ||
|---|---|---|---|
| Ischemic (n=1,061) | Hemorrhagic (n=82) | P | |
| Age at stroke, y, range | 45.5–96.4 | 53.0–89.6 | |
| Age at stroke, y, median (IQR) | 74.1 (68.8, 79.2) | 73.3 (67.0, 79.8) | 0.54 |
| Women, No. (%) | 529 (49.9) | 41 (50.0) | 0.98 |
| Race, No. (%) | 0.05 | ||
| White | 742 (69.9) | 49 (59.8) | |
| Black | 319 (30.1) | 33 (40.2) | |
| Cohort, No. (%) | 0.03 | ||
| ARIC | 229 (21.6) | 17 (20.7) | |
| CHS | 324 (30.5) | 16 (19.5) | |
| FOS | 105 (9.9) | 5 (6.1) | |
| REGARDS | 403 (38.0) | 44 (53.7) | |
| Education, No. (%) | 0.10 | ||
| Less than high school | 196 (18.6) | 8 (9.9) | |
| Completed high school | 300 (28.5) | 27 (33.3) | |
| Some college, no degree | 256 (24.3) | 16 (19.8) | |
| College graduate or more | 301 (28.6) | 30 (37.0) | |
| Ischemic stroke subtype, No. (%) | |||
| Cardioembolic | 200 (18.8) | ||
| Large artery atherosclerotic | 77 (7.3) | ||
| Lacunar/small vessel | 207 (19.5) | ||
| Cryptogenic/other determined etiology | 471 (44.4) | ||
| Missing | 106 (10.0) | ||
| Follow-up time after stroke, global cognition, y, median (IQR) | 5.8 (3.1, 9.2) | 6.9 (4.2, 9.5) | 0.30 |
| Follow-up time after stroke, executive function, y, median (IQR) | 5.4 (2.8, 8.6) | 6.2 (3.2, 8.9) | 0.46 |
| Follow-up time after stroke, memory, y, median (IQR) | 5.4 (2.6, 8.4) | 6.9 (3.9, 9.6) | 0.045 |
| SBP at first post-stroke cognitive assessment, mmHg, mean (SD) | 138.9 (23.8) | 138.2 (20.4) | 0.85 |
| No. SBP measurements after stroke, median (IQR) | 1.0 (1.0, 2.0) | 1.0 (1.0, 2.0) | 0.70 |
| Time from stroke to first post-stroke SBP, y, median (IQR) | 2.0 (0.7, 4.4) | 2.3 (0.7, 4.5) | 0.76 |
| Glucose at first post-stroke cognition, mg/dL, mean (SD) | 111.7 (37.4) | 105.8 (12.8) | 0.47 |
| No. glucose measurements after stroke, median (IQR) | 1.0 (1.0, 1.0) | 1.0 (1.0, 1.0) | 0.25 |
| Time from stroke to first post-stroke glucose, y, median (IQR) | 2.5 (1.1, 4.7) | 2.8 (1.0, 4.8) | 0.78 |
| LDL cholesterol at first post-stroke cognition, mg/dL, mean (SD) | 99.5 (36.6) | 109.9 (33.3) | 0.15 |
| No. LDL cholesterol measurements after stroke, median (IQR) | 1.0 (1.0, 1.0) | 1.0 (1.0, 1.0) | 0.09 |
| Time from stroke to first post-stroke LDL cholesterol, y, median (IQR) | 2.8 (1.3, 5.4) | 3.0 (1.0, 4.8) | 0.41 |
| Pre-stroke cumulative mean cognitive scores | |||
| Global cognition, median (IQR) | 52.6 (47.9, 56.5) | 53.5 (49.6, 57.1) | 0.14 |
| Executive function, median (IQR) | 49.9 (43.5, 54.8) | 51.6 (44.8, 57.2) | 0.16 |
| Memory, median (IQR) | 53.8 (50.0, 57.4) | 55.3 (52.1, 57.4) | 0.01 |
| No. pre-stroke cognitive assessments | |||
| Global cognition, median (IQR) | 4.0 (2.0, 7.0) | 4.0 (2.0, 6.0) | 0.85 |
| Executive function, median (IQR) | 2.0 (1.0, 4.0) | 2.0 (1.0, 3.0) | 0.01 |
| Memory, median (IQR) | 3.0 (2.0, 6.0) | 3.0 (2.0, 5.0) | 0.75 |
| Cognitive scores at first post-stroke assessment | |||
| Global cognition, median (IQR) | 49.8 (40.4, 57.8) | 50.2 (42.6, 58.3) | 0.46 |
| Executive function, median (IQR) | 44.9 (37.9, 52.4) | 47.2 (40.8, 52.8) | 0.17 |
| Memory, median (IQR) | 49.3 (43.5, 57.4) | 49.2 (49.1, 57.4) | 0.59 |
| No. post-stroke cognitive assessments | |||
| Global cognition, median (IQR) | 4.0 (2.0, 9.0) | 7.0 (2.0, 12.0) | 0.01 |
| Executive function, median (IQR) | 3.0 (2.0, 4.0) | 3.0 (2.0, 4.0) | 0.24 |
| Memory, median (IQR) | 3.0 (1.0, 6.0) | 5.0 (2.0, 8.0) | 0.006 |
SBP, systolic blood pressure; LDL, low-density lipoprotein.