Table 2.

Determining the diagnostic potential of PsEVs-derived amyloid-β (1–42), p-Tau, IL-1β, TNF-α, GFAP, and synaptophysin

S. no	Markers	Subject groups	AUC values	Sensitivity (%)	Specificity (%)	p-value
1	Amyloid-β (1–42)	AMC v/s MCI	0.9347	92	80	< 0.0001
2		AMC v/s AD	0.9862	91.43	96.67	< 0.0001
3		AD v/s MCI	0.8457	80	72	< 0.0001
4	p-Tau	AMC v/s MCI	0.8760	88	83.33	< 0.0001
5		AMC v/s AD	0.9757	94.29	83.33	< 0.0001
6		AD v/s MCI	0.9074	88.57	92	< 0.0001
7	IL-1β	AMC v/s MCI	0.9520	96	86.67	< 0.0001
8		AMC v/s AD	0.9857	94.29	90	< 0.0001
9		AD v/s MCI	0.9114	85.71	92	< 0.0001
10	TNF-α	AMC v/s MCI	0.8920	84	80	< 0.0001
11		AMC v/s AD	0.9848	88.57	96.67	< 0.0001
12		AD v/s MCI	0.9280	88.57	96	< 0.0001
13	GFAP	AMC v/s MCI	0.8393	88	76.67	< 0.0001
14		AMC v/s AD	0.8814	91.43	76.67	< 0.0001
15		AD v/s MCI	0.7657	74.29	72	0.0005
16	Synaptophysin	AMC v/s MCI	0.8507	80	86.67	< 0.0001
17		AMC v/s AD	0.9738	88.57	96.67	< 0.0001
18		AD v/s MCI	0.8291	85.71	68	< 0.0001

Abbreviations: TNF-α Tumor necrosis factor-alpha, GFAP Glial fibrillary acidic protein. Receiver operating characteristic (ROC) curves of all PsEVs derived-protein were performed, where the area under the ROC curve (AUC) is tabulated with p-value