Table 3.

Correlation analysis of PsEVs-derived amyloid-β (1–42), p-Tau, IL-1β, TNF-α, GFAP, and synaptophysin with neuropsychological scores

S. no	Markers	PsEVs concentration	ACE-III scores	MMSE scores
1	Amyloid-β (1–42)	r = 0.7196	r =  − 0.5107	r =  − 0.5276
2	p-Tau	r = 0.7960	r =  − 0.5055	r =  − 0.6081
3	IL-1β	r = 0.7220	r =  − 0.5684	r =  − 0.5743
4	TNF-α	r = 0.6473	r =  − 0.6110	r =  − 0.5522
5	GFAP	r = 0.5155	r =  − 0.5024	r =  − 0.4596
6	Synaptophysin	r = 0.5356	r = 0.5036	r = 0.5428

viz., Addenbrooke Cognitive Examination (ACE-III) and Mini-Mental State Examination (MMSE) scores

Abbreviations: TNF-α Tumor necrosis factor-alpha, GFAP Glial fibrillary acidic protein. Spearman correlation was used for correlation analysis