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. 2024 Jun 20;17:40. doi: 10.1186/s13041-024-01112-7

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Sex-divergent and sex-specific DTU. (A-B) Representative cartoons exemplify two transcript expression patterns of isoform switching: sex-divergent (A) and sex-specific (B). (C) Switchplot displaying a transcript summary, DGE (Wald test with BH correction p < 0.05, purple), DTE (Wald test with BH correction p < 0.05, cyan), and DTU (analysis of deviance chi-squared test with BH correction p < 0.05, green) of the sex-divergent gene Mtcl1 in the cortex between females (F; light color) and males (M; dark color). (D) Switchplot displaying a transcript summary, DGE (Wald test with BH correction p < 0.05, purple), DTE (Wald test with BH correction p < 0.05, cyan), and DTU (analysis of deviance chi-squared test with BH correction p < 0.05, green) of the sex-specific gene Rab28 in the striatum between females (F; light color) and males (M; dark color). Please note that these plots do not display all possible transcript structures of this gene, only the ones measured in our dataset. In the indicated comparison, ns denotes not significant and * denotes P < 0.05