Table 1.

Sex differences in Alzheimer’s disease therapeutic opportunities.

Drugs		Therapy effects
		Male	Female
ChEIs	Rivastigmine	++a	++b
	Donepezil	NA	NA
	Galantamine	NA	NA
Anti-NMDA	memantine	NA	−
Disease modifying therapy	Lecanemab	++	+
	Donanemab	+	++
HT	Estrogen	NA	++
	Androgen	++	+

^arepresents that the therapeutic efficacy occurred in the early stage of AD; ^brepresents that the therapeutic efficacy occurred in the later stage of AD; + represents the general therapeutic efficacy; ++ represents the better therapeutic efficacy; − represents poor therapeutic efficacy; NA represents that the therapeutic efficacy is unclear.

AD, Alzheimer’s disease; ChEIs, Cholinesterase inhibitors; Anti-NMDA, anti-N-methyl-D-aspartate; HT, Hormone therapy.