Table 2.
Sex differences in depression’s therapeutic opportunities.
| Drugs | Therapy effects | |
|---|---|---|
| Male | Female | |
| TCA | ++ | + |
| SSRI | + | ++ |
| ketamine | a | b |
| HT | ||
| Estrogen | NA | ++ |
| Testosterone | ++ | NA |
| Other therapies | ||
| Lifestyle interventions | + | ++ |
| vitamin D | NA | ++ |
| ECT | + | + |
a The therapeutic efficacy is sensitive; b The therapeutic efficacy is lasting effects; + represents the general therapeutic efficacy; ++ represents the better therapeutic efficacy; − represents poor therapeutic efficacy; NA represents that the therapeutic efficacy is unclear.
AD, Alzheimer’s disease; ECT, Electroconvulsive therapy; HT, Hormone therapy; SSRIs, Selective serotonin reuptake inhibitors; TCA, Tricyclic.