Table 2.
The inflammatory responses of S. maltophilia and 610A2T infected mice and TB patient.
| Cytokines | Classification | S. maltophilia | 610A2T | TB patient3 | |
|---|---|---|---|---|---|
| A/J mice 1 | DBA/2 mice2 | KM mice | |||
| TNF-α | Pro- | *↑ | *↑ | *↑ | *↑ |
| IFN-γ | Pro- | *↑ | *↑ | *↑ | *↑ |
| GM-CSF | Adaptive | – | – | *↑ | *↑ |
| IL-1β | Pro- | – | *↑ | – | ns |
| IL-2 | Adaptive | – | ns↓↑ | *↑ | *↑ |
| IL-4 | Adaptive | – | *↓ | *↑ | *↑ |
| IL-5 | Adaptive | – | ns↑↓ | – | ns |
| IL-6 | Pro- | *↑ | *↑ | *↑ | *↑ |
| IL-10 | Anti- | – | ns↓↑ | *↑ | *↑ |
| IL-12 | Anti- | – | *↑ | ns | *↑ |
| IL-17A | Pro- | – | – | *↑ | *↑ |
1 Data from (Rouf et al., 2011); 2 Data from (Di Bonaventura et al., 2010); 3 Data from (Mvubu et al., 2018). * cytokines having significantly different between infected and control mice; ns without statistical significance; – no included in study.
↑ the concentration of cytokine in the infection group is higher than that in the control group; ↓↑ during the observation period, the concentration of factors in the infection group is initially lower than that in the control group, and then increase to a level higher than that in the control group.