Extended Data Fig. 4.

Evidence for transfer of Dxl material via a circular DNA. Intermediate molecule. Dxl-12mau (green) is flanked by sat359 repeats 835 (blue arrows) and by CARPB intronic sequence (boxes labelled A and B). These flanking sequence match sequences present in Dxl-10mau and Dxl-14mau, but 836 the order of the two CARPB segments A and B differs from Dxl-12mau. The re-ordering of homologous sequences, as well as their intervening sequence, is 837 consistent with a transfer of material via circular DNA intermediate.