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. 2024 May 16;17(3):e004374. doi: 10.1161/CIRCGEN.123.004374

Figure 2.

Figure 2.

Cell type composition changes. Peripheral blood mononuclear cells (PBMCs) of patients with ST segment–elevated myocardial infarction (STEMI) (t0, t24h, and t6–8w) and controls presented in uniform manifold approximation and projections (UMAPs): A, showing the 10 major; B, 29 minor cell types. C, Proportions of monocytes (major class and its 2 subtypes) and (D) natural killer (NK) cells (major class and its 2 subtypes) in controls and post-STEMI. ASDC indicates AXL SIGLEC6 dendritic cell; C, control; cMono, classical monocytes; CTL, cytotoxic T cell; cDC, conventional dendritic cell; HSPC, hematopoietic stem and progenitor cell; ILC, innate lymphoid cell; MAIT, mucosal associated invariant T cell; ncMono, nonclassical monocytes; pDC, plasmacytoid dendritic cell; TCM, T-central memory; and TEM, T-effector memory. Significant Holm’s adjusted P value *P<0.05, **P<0.01, ***P<0.001. Each donor’s proportion depicts a cell count-weighted data point, each boxplot the weighted median, 25th and 75th percentile.