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. 2024 Jun 10;17(3):e004369. doi: 10.1161/CIRCGEN.123.004369

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© 2024 The Authors.

Circulation: Genomic and Precision Medicine is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.

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Figure 4. — Comprehensive overview of alterations in energy metabolism and lipid-handling pathways in patients with hypertrophic cardiomyopathy (HCM) vs nonfailing (NF) donors integrating metabolomics, lipidomics, and proteomics data. Metabolomic, lipidomic, and proteomic data were integrated to provide an overview of changes in major energy metabolism and lipid-handling pathways. Metabolites and lipids are indicated by objects with a dark fill and white text; proteins are indicated by objects with a light fill and black text. Blue, orange, and gray indicate lower, higher, and unchanged abundances in HCM vs NF donors, respectively. Created with BioRender.com.