Table 6.
Mutations in protein-coding genes in S. enterica and S. aureus after 6 days of ARM-1 treatment with and without the indicated antibiotics (ND: none detected)
| Species | Treatment | Replicate | Mutations |
|---|---|---|---|
| Salmonella enterica | ARM-1 | 1 | ND |
| 2 | ND | ||
| 3 | ND | ||
| 4 | ND | ||
| 5 | ND | ||
| 6 | ND | ||
| Rif + ARM-1 | 1 | ND | |
| 2 | D147A (murC) I572L (rpoB) S82A (serB) | ||
| 3 | I572N (rpoB) | ||
| Trim + ARM-1 | 1 | M199T (cpxR) | |
| 2 | M199T (cpxR) | ||
| 3 | Q34I (ygdP) | ||
| Staphylococcus aureus | ARM-1 | 1 | ND |
| 2 | ND | ||
| 3 | N90I (SAOUHSC_01556) | ||
| 4 | E183* (yjbH) | ||
| 5 | ND | ||
| 6 | ND | ||
| Rif + ARM-1 | 1 | Q137L (rpoB) I527L (rpoB) | |
| 2 | L466S (rpoB) D471G (rpoB) | ||
| 3 | S486L (rpoB) | ||
| Trim + ARM-1 | 1 | ND | |
| 2 | ND | ||
| 3 | ND |