Table 6.
Mutations in protein-coding genes in S. enterica and S. aureus after 6 days of ARM-1 treatment with and without the indicated antibiotics (ND: none detected)
Species | Treatment | Replicate | Mutations |
---|---|---|---|
Salmonella enterica | ARM-1 | 1 | ND |
2 | ND | ||
3 | ND | ||
4 | ND | ||
5 | ND | ||
6 | ND | ||
Rif + ARM-1 | 1 | ND | |
2 | D147A (murC) I572L (rpoB) S82A (serB) | ||
3 | I572N (rpoB) | ||
Trim + ARM-1 | 1 | M199T (cpxR) | |
2 | M199T (cpxR) | ||
3 | Q34I (ygdP) | ||
Staphylococcus aureus | ARM-1 | 1 | ND |
2 | ND | ||
3 | N90I (SAOUHSC_01556) | ||
4 | E183* (yjbH) | ||
5 | ND | ||
6 | ND | ||
Rif + ARM-1 | 1 | Q137L (rpoB) I527L (rpoB) | |
2 | L466S (rpoB) D471G (rpoB) | ||
3 | S486L (rpoB) | ||
Trim + ARM-1 | 1 | ND | |
2 | ND | ||
3 | ND |