Table 1. MRI features-based types of cerebral CMs and histopathologic correlation 19 .
Type | MRI signals | Histopathology | ||
---|---|---|---|---|
T1-weighted signal intensity | T2-weighted signal intensity | Signal intensity on SWI or T2 gradient echo sequence | ||
I | Hyperintense | Heterogeneous signals with a hypointense rim | Hypointense | Subacute hemorrhage surrounded by hemosiderin stain macrophages and gliotic brain |
II | Heterogenous with classic “popcorn” appearance | Heterogenous with classic “popcorn” appearance | Hypointense | Loculated areas of hemorrhage and thrombosis of varying age surrounded by hemosiderin-stained brain and gliosis |
III | Hypointense and isointense | Hypointense and isointense | Hypointense | Chronic resolved hemorrhage with hemosiderin staining within and around the lesion |
IV | Poorly seen tiny, often multiple, punctate foci with low signals | Poorly seen tiny, often multiple, punctate foci with low signals | Hypointense | Multiple areas of hemosiderin deposition without a central core |
Abbreviations: CM cavernous malformation; MRI magnetic resonance imaging; SWI susceptibility-weighted imaging.