Table 1.
Order of drug selection for the acute management of dyskinetic crisis and basal movement disorder in GNAO1-RD.
| Acute treatment for dyskinetic crisis | ||||||||
|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 |
| Clonazepam | Clonazepam | Diazepam | Clonazepam | Clonazepam | Clonazepam | Tetrabenazine | Diazepam | Clonidine |
| Diazepam | Diazepam | Clonazepam | Diazepam | Clonidine | Diazepam | Clonidine | Clonazepam | Clonazepam |
| Clonidine | Clonidine | Chloral hydrate | Chloral hydrate | Diazepam | Clonidine | Trihexyphenidyl | Chloral hydrate | Carbamazepine |
| Chloral hydrate | Carbamazepine | Clonidine | Clonidine | Chloral hydrate | Chloral hydrate | Amitriptyline | Clonidine | Gabapentin |
| Baclofen | Gabapentin | Gabapentin | Baclofen | Gabapentin | Gabapentin | Clonidine | Baclofen | Baclofen |
| Carbamazepine | Topiramate | Baclofen | Gabapentin | Carbamazepine | Baclofen | Clonazepam | Gabapentin | Diazepam |
| Topiramate | Baclofen | Carbamazepine | Carbamazepine | Topiramate | Carbamazepine | Diazepam | Carbamazepine | Topiramate |
| Midazolam | Chloral hydrate | Topiramate | Topiramate | Baclofen | Topiramate | Baclofen | Topiramate | Chloral hydrate |
| Tetrabenazine | Midazolam | Midazolam | Carbamazepine | |||||
| Gabapentin | ||||||||
| Topiramate | ||||||||
| Chloral hydrate | ||||||||
| Chronic treatment for basal movement disorders | ||||||||
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 |
| Tetrabenazine | Clonazepam | Tetrabenazine | Tetrabenazine | Tetrabenazine | Trihexyphenidyl | Trihexyphenidyl | Clonazepam | Clonazepam |
| Clonazepam | Gabapentin | Clonidine | Trihexyphenidyl | Clonazepam | Lorazepam | Tetrabenazine | Gabapentin | Diazepam |
| Diazepam | Tetrabenazine | Clonazepam | Gabapentin | Gabapentin | Gabapentin | Clonidine | Clonidine | Gabapentin |
| Clonidine | Trihexyphenidyl | Gabapentin | Clonazepam | Baclofen | Clonazepam | Clonazepam | Baclofen | Carbamazepine |
| Chloral hydrate | Clonidine | Diazepam | Diazepam | Diazepam | Clonidine | Topiramate | Chloral hydrate | Clonidine |
| Baclofen | Carbamazepine | Baclofen | Baclofen | Carbamazepine | Baclofen | Baclofen | Diazepam | Chloral hydrate |
| Carbamazepine | Topiramate | Carbamazepine | Clonidine | Clonidine | Chloral hydrate | Gabapentin | Carbamazepine | Baclofen |
| Gabapentin | Diazepam | Chloral hydrate | Chloral hydrate | Topiramate | Diazepam | Diazepam | Topiramate | Topiramate |
| Topiramate | Baclofen | Topiramate | Carbamazepine | Chloral hydrate | Carbamazepine | Carbamazepine | ||
| Chloral hydrate | Topiramate | Topiramate | Chloral hydrate | |||||
| First choice | ||||||||
| Second choice | ||||||||
| Third choice | ||||||||
Each number represents the opinion of one of the participating experts.