TABLE 3.
Incidence of mortality after i.c. inoculationa
| Inoculation | Viral dose (PFU, 103) | Time of death (days p.i.) | Mortality (%) |
|---|---|---|---|
| KOS | 0.25 | 0 | |
| 0.5 | 4, 5, 5 | 37 | |
| 0.75 | 10, 11 | 25 | |
| 1.5 | 3, 3, 3, 4, 7 | 58 | |
| 2.0 | 5, 5, 6, 7 | 50 | |
| 3.0 | 2, 3, 3, 3, 3, 4, 4, 7 | 100 | |
| 6.0 | 2, 3, 3, 3, 3, 3, 5, 6 | 100 | |
| VB | 0 |
Animals were observed from 60 to 240 days p.i. There were 8 animals at each dose of HSV-1 KOS and 12 animals in the control VB group. These animals were different from those described in Table 2. Surviving animals after inoculations of 5 × 102 to 20 × 102 PFU of KOS were used in the G207 challenge studies (Table 4).